《Journal of the Formosan Medical Association》
Volume 122, Issue 3, March 2023, Pages 230-238
Nano-SnO₂ Coating Enhances Osseointegration: Study Led by Dr. Shang-Chan Chiu Explores ALD Application in Dental Implants
（邱上展醫師研究成果：植體表面以原子層沉積技術奈米氧化錫膜之表現）
To improve the surface properties and osseointegration potential of dental implants, Dr. Shang-Chan Chiu and his research team employed atomic layer deposition (ALD) to apply nanoscale tin oxide (SnO₂) coatings to titanium surfaces.
Published in the Journal of the Formosan Medical Association, the study examined how coating thicknesses of 0, 20, 50, and 100 nm affect surface morphology and biocompatibility.
Results showed that thicker coatings reduced microscale roughness but enhanced nanoroughness, leading to more polygonal, spread-out cell morphology. Although early cell viability was slightly reduced in coated groups by Day 4, significantly higher osteocalcin (OCN) expression was observed by Day 14, indicating stronger osteogenic differentiation.
Dr. Chiu highlights that the ALD technique allows for precise, pinhole-free nanoscale coatings, which may enhance both the physical interface and long-term integration of dental implants.
Published in the Journal of the Formosan Medical Association (SCI-indexed, Elsevier)（原文連結）