The influence on surface characteristic and biocompatibility of nano-SnO₂-modified titanium implant material using atomic layer deposition technique
Nano-SnO₂ Coating Enhances Osseointegration
To improve the surface properties and osseointegration potential of dental implants, Dr. Shang-Chan Chiu and his research team employed atomic layer deposition (ALD) to apply nanoscale tin oxide (SnO₂) coatings to titanium surfaces.
Published in the Journal of the Formosan Medical Association, the study examined how coating thicknesses of 0, 20, 50, and 100 nm affect surface morphology and biocompatibility.
Results showed that thicker coatings reduced microscale roughness but enhanced nanoroughness, leading to more polygonal, spread-out cell morphology. Although early cell viability was slightly reduced in coated groups by Day 4, significantly higher osteocalcin (OCN) expression was observed by Day 14, indicating stronger osteogenic differentiation.
Dr. Chiu highlights that the ALD technique allows for precise, pinhole-free nanoscale coatings, which may enhance both the physical interface and long-term integration of dental implants.
邱上展醫師參與之研究成果，發表於國際期刊《Journal of the Formosan Medical Association》（SCI 收錄）。
本研究透過「原子層沉積技術（ALD）」，在牙科植體表面鍍上奈米級氧化錫（SnO₂）薄膜，探討不同厚度塗層對於植體表面特性與骨整合能力的影響。
代表植體與骨組織介面整合能力的重新優化。
研究結果顯示，奈米塗層可改變植體表面微結構，促進細胞附著與分化，並在後期顯著提升骨生成相關指標（如 osteocalcin 表現），顯示其在提升植體穩定性與長期整合方面具有潛在優勢。
邱上展醫師指出，透過精準的奈米塗層技術，可在不影響整體結構的前提下，優化植體與骨組織的接觸介面，未來有助於提升植牙治療的成功率與穩定性。
這項研究對植牙治療有什麼實際幫助？
此研究顯示，透過奈米塗層技術可改善植體表面特性，促進骨細胞分化與整合，進而提升植牙的穩定性與長期成功率。邱上展醫師長期關注材料科學與臨床應用的結合，致力於將最新研究成果轉化為實際治療品質的提升。